Nobody understands why it all helps, they just noticed it does work for something, quickly pushed it to the market first to get patents and get all the profits from it before generics + derivatives hit their pockets. Now, everyone is studying it because there's all new funding coming in for it and finding other versions of it that they can profit off it.
Nobody knows what migraine really is, so this isn't a surprise to them that GLP-1 may help, the main question is; why? So they have another data point proving that gut health has a direct correlation to the brain.
Keep in mind that a lot of the benefits go away once patients come off GLP-1 and we have not seen any studies yet on what happens to people who come off it for long term effects. It may in fact make things even worse and for a lot of people, they may have to stay on it for the rest of their lives.
> [...] quickly pushed it to the market first to get patents and get all the profits [...]
Beyond what others have commented already, especially on obesity and cardiovascular disease, I have to correct this specifically, because it is a very common and honestly understandable misunderstanding people have about these drugs.
While only having appeared in the public consciousness comparatively recently, this class of drugs has been in use for two decades at this stage [0], showcasing a very solid safety profile with well established side-effects [1].
Continued research is important, as is proper prescription and use under the care of a Medical Professional up-to-date on current day evidence based practices (as is the case with all interventions), but to have a proper discussion about these, we shouldn't spread myths such as this being "quickly pushed" out, as these have undergone the clinical trials and regulations established across multiple agencies from multiple governments [2].
Again, it is understandable why these are considered rather new or appeared suddenly, especially if one doesn't take a look into their approval, but I don't see any evidence for them being rushed out or anything of the sort.
Right, at this point it's not "we don't understand what negative impacts it could have", it's "only just now are people realizing that it also has these other positive side-effects".
> Keep in mind that a lot of the benefits go away once patients come off GLP-1 and we have not seen any studies yet on what happens to people who come off it for long term effects.
Not if they increase muscle mass and change their lifestyle, like every physician (and the FDA/pharma companies) recommend.
> It may in fact make things even worse and for a lot of people, they may have to stay on it for the rest of their lives.
It does not. And some people may.
You know what’s worse than taking a GLP-1 forever? Obesity or metabolic syndrome killing you before you get to “forever.”
Benefits of reading, swimming, walking, playing an instrument etc. will go away too if you stop doing that thing.
Biology rarely awards something "forever". Maybe one day we can "fix" obese metabolisms permanently by killing off some receptors etc., but in that case, I would be afraid of intractable long-term effects even more.
The idea that drugs shouldn't be taken forever just doesn't make any sense. There are plenty of forever diseases, naturally those should require forever drugs.
Just an update, because I think my last point wasn't clear.
I'm not saying forever drug is a bad thing. I'm saying people who wants to take GLP-1 as a temp drug to lose weight quickly and get off it may not realize the long term impact it may have on their body.
For an example, certain type of anti-depressants has serious side effect that if not carefully tapered off and managed with a different drug, can leave folks with cluster headaches that lasted several months if not years.
Yes. Gut microbes has already been shown to have a great impact on how we metabolize by what med we take, what we eat or drink and intake from our environments (micro-plastics, etc).
There is no single main root cause for obesity. We just combine it as one because there isn’t a lot of long term research or funding for it right now. There is a lot of sigma against obesity and people keep blaming other people instead.
Thyroid hormone disorders have been linked to cause weight gains. This can’t be fixed by simply eating less, it can literally do far more damage.
Medications have been linked to cause weight gain as side effects. This wouldn’t do anything to eat less until they stop taking meds and for some, they cannot do that.
Americans’ increasing desire for sweets have increased the sugar content in all of our food including the fruits and vegetables over time. We’ve intentionally bred our healthy stuff to be sweeter. So eating less can make us even more hungrier because we go into sugar crush without realizing it. Changing diets is difficult without us doing all sorts of calculations of finding the right cheap healthy food at the right store and that is you are lucky enough to have any.
Can you show me what we're doing in USA to help children and people develop the habits and discipline for long term lifestyle change?
Because I've never learned anything about nutrition, macros, high sugar content and all of the healthy food I should learn to eat on my own.
We did not have home classes in any of my education in US at all, they were a thing in the past but that wasn't a thing in my middle hs or hs or college at all in NY in 90s/2000s.
All of my bad habits were from my parents and they were not good eaters.
Yep, that’s key. That’s the lesson I learned as I commented above as GP.
My work offered me five visits with a dietician and then I got a health coach and a nurse all paid for and monitoring me on the side through the Vida service. Not everyone has that
There's a framework that works, also, there's a framework that would prevent the current problems. Obviously, some problems are easier to solve if there's something that you can trust to fundamentally work.
Great news app. Not only does it learn which news you'd like to follow, its AI feature is actaully useful for a change (for me at least); it extracts the data you want to know about and it has a few useful views such as the "opposite views" primpt that I really like using to learn from both sides.
Related articles are great to reduce duplicates and being able to ask questions or seeing questions from other users was great to see.
We can’t prevent the technology from being invented, it was always going to happen (video games and VR was practically going to have this AI generated worlds).
It is just a matter of doing it right the first time such as having license/agreements or company building it based on their own images.
just because we can't prevent something from being invented, doesn't mean we can't prevent its spread: we limit technology all the time
like chemical weapons were invented, bioweapons were invented, meth manufacturing was invented, but we prohibit people from manufacturing them because they're harmful
same logic could apply to generative machine learning (obv not as harmful as above examples, but same idea)
It seems pretty surprising to me that you can already tell where generative models are going, and that they should be stopped in their tracks immediately. Is there any documented harm yet?
literally any website containing images is in most cases overwhelmed with an unlimited supply of ai generated garbage
ai image generators are barely two years old, and have already caused a lot of damage in basically every sphere they interact with, i'd say you don't need a lot of foresight to be able to make a judgement here
That’s not what the OP said though, what you’re describing is basically regulations. All we can do is regulate to outlaw and punish those who don’t comply with it but that’s still not possible to limit.
Chemical weapons are still being developed (Russia used it in their war against Ukraine), bioweapons are still being developed, meth are still being manufactured all over in US if not smuggled in.
A lot of stores don't accept them anymore because of scumbag scammers abusing the system, leaving us dependent on a friend or family member to make our calls.
It is. But when the front line person has received a bunch of spam calls they start hanging up when they hear the relay disclaimer at the start of the call, whatever the law says.
Nobody knows what migraine really is, so this isn't a surprise to them that GLP-1 may help, the main question is; why? So they have another data point proving that gut health has a direct correlation to the brain.
Keep in mind that a lot of the benefits go away once patients come off GLP-1 and we have not seen any studies yet on what happens to people who come off it for long term effects. It may in fact make things even worse and for a lot of people, they may have to stay on it for the rest of their lives.