free floating spike in vitro cultured human cells developed pathological state.
when a spike protien is expressed as an insertion into the cytoplasmic membrane there is very limited mobility, and less potential to approach ACE2 with appropriate orientation and energy for receptor ligand-interaction to occur, this would result in somewhat less interaction of the spike with the rennin angiotensin system[RAS]. a concern would be the possible development of abberant or deletion type spike protiens translated from undesirerable spike-mRNA species, the scenario of most concern would be a spike protien with malformed or deleted transmembrane domains, thus allowing a speudo spike protien to move freely outside the host cell.
this doesnt indicate that there is an unconceived problem, this publication is recognizing that perturbations of the RAS are highly consequential; a major part of covid pathology; and a hidden gotcha, should vaccine development ever become cavalier regarding RAS signaling and spike based agents
Not at all. But since the time this was published many people have been vaccinated and we have a lot of data that the researchers didn’t have at the time of publication. The Speculation in the article, while totally valid at the time, should be replaced by a comprehensive analysis of the available data.
The pulmonary hypertension they worry about is hard to detect and takes a few years to kill you. A few months may not be enough for it to have become noticeable.
I would think the recent concerns around myocarditis indicate there may be some reason to take the article's speculation about potential cardiac effects seriously.
