That's exactly what I do - I build a monolith using the self-contained deployment feature and zip it up to the server to run.
The management of certificates, configuration, etc. is built directly into any product I work on. Outsourcing this stuff to IIS, et. al. is exactly how you wind up hating all of this tech in the first place.
Prerequisites are zero if you do this right. I can take a blank EC2 server, copy the binaries over and run them immediately. I don't even have to install any runtimes or SDKs.
Modern .NET contains the web server. It's not an external thing anymore. You include a .NET library to host your stuff. Check out the minimal api reference: