No, at least not in VoiceOver, which I use. In my experience, screen readers/assistants don't mimic the left/middle/right click of the mouse [0]. You often get two options: left click and double click [1]. There is also a right-click menu (control space), but unless it is based on a system-native UI, it is likely to be unusable for SR.
[0]: It is even easier to not use a mouse, when you are using an assistant. With a keyboard and VO you can resize, drag and drop and do many more activities.
Uh, that's interesting, but it does not work for me :(
AFAIK, VO+Command+Return can be used to select multiple things, not to click. For example, in the file viewer (Finder.app, similar to Nautilus/explorer.exe), it is similar to pressing Control (win/linux) and the left mouse button when the cursor is over a file to add it to the selection.
Edit: To open a page in a new tab in a Firefox with stock VoiceOver, I need to press VO+Shift+M to open context menu (aka right-click menu), and then select an option from the list (by greping, using arrows etc.).
VoiceOver is most often, and best, paired with Safari.
By default, Command-Return, no VO key, opens a focused link in a new tab behind the current tab. It's not a VoiceOver-specific keyboard command. It also works in Firefox and Chrome.
However, by default, Safari does not focus links when pressing the Tab key, you need to go to Settings > Advanced and check "Press Tab to highlight each item on a webpage" first.
[0]: It is even easier to not use a mouse, when you are using an assistant. With a keyboard and VO you can resize, drag and drop and do many more activities.
[1]: https://support.apple.com/en-us/guide/voiceover/mchlp2746/10...