One probably has to be perfect - not just good with opsec - to maintain anonymity from the government. The FBI has multiple side-channels, such as agents physically tracking if you're home at your "super-secure" 7-VPN computer when your Internet persona is active online
You can be good and yet the heavy hand of the law still gets you. They got Escobar and "El Chapo" Guzmán too. And his operation was smaller than either of those fine gentlemen's.