My wife keeps complaining that Beyond Good and Evil doesn't work... but last I checked it didn't work on Windows either, thanks to Ubisoft buggy DRM and some other issue I forgot.
I don't know what it was like to use Windows anymore. It almost feels like I have never used Windows in the first place, and yet when I look back to the year I switched. 2018, when Proton was released, I am still kind of shocked how recent that is as a former user of Windows XP, Vista, 7 and Windows 10.
I cannot tell you the last time I have come across something that doesn't work via Proton.
It is one of the many crown jewels of Valve.
EDIT - ’From dust’ released in 2009 still doesn't work but that is due to Ubisofts awful DRM infrastructure.