Keep in mind that very commonly accepted safe substances such as carrots or water also become lethal at high enough doses, for all humans. It's often stated, and it can be tiring to hear, but the dose really does make the poison.
And context matters. Folks with this or that kidney problems can die from basically nothing while the median bloke doesn't even notice that their piss is a tad darker.
That's an excellent point, and of course individuals can have pretty stark differences in metabolism, with the alcohol flush reaction being a great and highly visible example.
