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My understanding has always been that you habituate to melatonin after a few days. Is this not true?


I don't believe there is any evidence that you develop a tolerance. As a side note, Melatonin changed my life.


The body will develop a tolerance (or the reverse, a sensitization reaction) to just about any substance that's taken regularly due to homeostasis. However, so long as you're taking a dose that nudges some physiologic signal/need in the right direction, your body's response to the substance will be minimal.

I'd be surprised if you can find anything this isn't true for.

A lack of studies on what the tolerance looks like for a particular substance does not imply that tolerance does not form.

In the case of melatonin: It's almost universally true that your sleep quality is worse than it was before once you stop taking it (for a few days at least). That's an indication that your body's equilibrium has changed from habitual use.


Melatonin does have the potential for augmentation, but it isn’t a certainty or even the majority of people.

Oddly, the result isn’t a loss of initial efficacy but instead a ‘wide awake at 3am’ situation.


Not in my case. Never had this sleep quality. But maybe it's placebo after a few weeks? :)


FYI it's unlikely you will eventually develop a tolerance, but it's important to not increase dosage: https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-mi...


The linked article doesn't mention tolerance at all? I don't believe there is any evidence out there to suggest that melatonin tolerance is a thing.


You're right! Edited the post...thanks for pointing this out was actually a mistake on my part the article was about incorrect dosage which was the point I wanted to make.


Ahh then yes that's a super valid point. I've seen shops sell 10mg per tablet. 0.5mg already does the trick for me.




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