As a user of NoScript + Firefox and as a developer of a browser with an express goal of "privacy by default"[1], I am thrilled to see this getting more attention. The more people use privacy features, the more will website developers ensure that their products degrade gracefully when, for example, third-party scripts are disabled. Which will enable even more users to migrate towards a "privacy by default" configuration. And hopefully, this will be a positive feedback cycle.
I use ublock with firefox. I worry the opposite will happen:
When a website doesn't work, you can look at the specific blocked domains and types of content and selectively unblock for the current domain, or you can be lazy and just turn off ublock for the current domain.
I worry that if tracking/ad blockers become very popular, then websites that don't work will be rewarded with all the tracking/ad blocking being turned off by most people.
I used to just use flashblock for click-to-play. I like the simplicity of that - it attacks the biggest problem in a totally generic way, and if the main content is flash, you can almost always just click on it.
A better option, and easier for users, would be for them to subscribe to a privacy setting upstream which configures popular sites for them. This would have to be non-canonical, such that popular upstream options that get influenced by advertisers can fall out of favor.
1: https://gngr.info/doc/introduction.html